New research analysis affirms the addition of the following structure function claims for VINIA® according to FDA Guidelines for Dietary Supplements:

• VINIA® prevents Lipid Oxidation
• VINIA® protects the body by preventing oxidative damage to the cells
• VINIA® reduces oxidation of LDL cholesterol

VANCOUVER, CANADA, and REHOVOT, ISRAEL, November 15, 2021 – BioHarvest Sciences Inc. (“BioHarvest” or the “Company”) (CSE: BHSC) reports that recent research analysis provides additional support for anti-oxidation structure/function claims of VINIA®. This analysis, when added to the clinical study [1] conducted by the Company, provides a clear substantiation to BioHarvest’s claims relating to anti-oxidation, lipid anti-oxidation, and scavenging free radicals.

The Company studied five Randomized Controlled Trials (RCT) [2] that were conducted with grapes in the form of red wine and juice, and which reported decreased LDL-C oxidation as well as reduction in DNA oxidative damage and other oxidative outcomes. Meta-analysis [3] of four RCTs found that grape polyphenols reduced LDL-C oxidation both with respect to the control group and with respect to baseline. This meta-analysis provides additional support that VINIA® has the beneficial effect of decreasing lipid oxidation, given that VINIA® red grape powder boasts the full spectrum of the active red grape ingredients (all polyphenols, including Piceid-Resveratrol).

Dr. Yochi Hagay, the CTO, said, “Cholesterol damages the cardiovascular functioning when it gets oxidized. The unique composition of VINIA® (that includes a complex of polyphenols with Piceid resveratrol) reduces the oxidation of the lipids as well as improves blood flow. These combined actions provide for an improved cardiovascular functioning. I believe that further clinical trials and research will prove additional important benefits of VINIA®.”

Ilan Sobel, the CEO, said “The unique functional capabilities of VINIA® are creating a significant demand for VINIA® across the USA, similar to the demand we have been experiencing in Israel. These additional structure function claims broaden the scope of benefits that VINIA® brings to the US consumers and will raise further awareness for the brand and no doubt continue to increase growth momentum.”

To access USA and Israel sales information, the Company refers readers to the press release issued on October 5, 2021 available at www.bioharvest.com.

 About BioHarvest Sciences Inc.

BioHarvest Sciences Inc. (CSE: BHSC) is a fast-growing Biotech firm listed on the Canadian Securities Exchange. BioHarvest has developed a patented bio-cell growth platform technology capable of growing the active and beneficial ingredients in fruit and plants, at industrial scale, without the need to grow the plant itself. This technology is economical, ensures consistency, and avoids the negative environmental impacts associated with traditional agriculture. BioHarvest is currently focused on nutraceuticals and the medicinal cannabis markets. Visit:www.bioharvest.com.

REFERENCES

[1] Reference for BioHarvest’s clinical trial

1. Nachum Vaisman and Eva Niv.Daily consumption of red grape cell powder in a dietary dose improves cardiovascular parameters: a double blind, placebo-controlled, randomized study”, 2015. Int J Food Sci Nutr. 66(3):342-966(3):342-9.

5. Toaldo, I.M., F.A. Cruz, E.L. da Silva, and M.T. Bordignon-Luiz. 2016. Acute consumption of organic and conventional tropical grape juices (Vitis labrusca L.) increases antioxidants in plasma and erythrocytes, but not glucose and uric acid levels, in healthy individuals. Nutr Res. 36:808-817

[2] References for the 5 RCTs

1. Gaiotti, and A. De Lorenzo. 2015. Changes in LDL Oxidative Status and Oxidative and Inflammatory Gene Expression after Red Wine Intake in Healthy People: A Randomized Trial. Mediators of inflammation. 2015:317348

2. Estruch, R., E. Sacanella, F. Mota, G. Chiva-Blanch, E. Antunez, E. Casals, R. Deulofeu, D.Rotilio, C. Andres-Lacueva, R.M. Lamuela-Raventos, G. de Gaetano, and A. UrbanoMarquez. 2011. Moderate consumption of red wine, but not gin, decreases erythrocyte superoxide dismutase activity: a randomised cross-over trial. Nutrition, metabolism, and cardiovascular diseases: NMCD. 21:46-53.

3. Guler, A., A. Candemir, O. Merken, F.B. Asiklar, Y. Dilli, and N. Yildiz. 2019. Determination of physical, biochemical and antioxidant properties and mineral composition of some new developed grape varieties and selected clones from Turkey. FRESENIUS ENVIRONMENTAL BULLETIN. 28:10146-10153.

4. Martins, N.C., G.P. Dorneles, A.S. Blembeel, J.P. Marinho, I.C.T. Proenca, M.J.V. da Cunha Goulart, G.B. Moller, E.P. Marques, D. Pochmann, M. Salvador, V. Elsner, A. Peres, C. Dani, and J.L. Ribeiro. 2020. Effects of grape juice consumption on oxidative stress and inflammation in male volleyball players: A randomized, double-blind, placebo-controlled clinical trial. Complement Ther Med. 54:102570.

5. Toaldo, I.M., F.A. Cruz, E.L. da Silva, and M.T. Bordignon-Luiz. 2016. Acute consumption of organic and conventional tropical grape juices (Vitis labrusca L.) increases antioxidants in plasma and erythrocytes, but not glucose and uric acid levels, in healthy individuals. Nutr Res. 36:808-817

[3] Reference for the meta-analysis

1. Lupoli, R., P. Ciciola, G. Costabile, R. Giacco, M. Minno, and B. Capaldo. 2020. Impact of Grape Products on Lipid Profile: A Meta-Analysis of Randomized Controlled Studies. J Clin Med. 9